Effects of methoxsalen from poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment

Jae Kyeom Kim, Soo Jung Choi, Hyeri Bae, Cho Rong Kim, Hong Yon Cho, Young Jun Kim, Seung Taik Lim, Chang Ju Kim, Hye Kyung Kim, Sabrina Peterson, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Previously, we identified methoxsalen (8-methoxy- 2′,3′,6,7- furocoumarin) as the bioactive compound probably responsible for acetylcholinesterase (AchE) inhibition achieved by feeding crude extract of Poncirus trifoliate. To confirm the activity of methoxsalen, Institute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing effects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. Methoxsalen effectively reversed TMT-induced memory impairment on both Y-maze and passive avoidance tests. Brain AchE activity was inhibited by the oral consumption of all concentrations of methoxsalen. Moreover, the level of oxidative stress was significantly ameliorated in the groups on methodsalen containing diets. This is the first in vivo study conducted with methoxsalen in the field of AD research, and it indicates that further investigation of methoxsalen is warranted.

Original languageEnglish (US)
Pages (from-to)1984-1989
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number10
DOIs
StatePublished - 2011

Bibliographical note

Funding Information:
This work was supported by the Grant from the Korean Ministry of Education, Science, and Technology (The Regional Core Research Program/Zero Energy Green Village Technology Center).

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Acetylcholinesterase
  • Alzheimer's disease
  • Anti-oxidative activity
  • Methoxsalen (8-methoxy-2′,3′,6 7-furocoumarin)
  • Poncirus trifoliata

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