Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Keli L. Hippen; Michael Loschi; Jemma Nicholls; Kelli P.A. MacDonald; Bruce R. Blazar

doi:10.3389/fimmu.2017.02014

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P.A. MacDonald, Bruce R. Blazar

Research output: Contribution to journal › Short survey › peer-review

45 Scopus citations

Abstract

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.

Original language	English (US)
Article number	57
Journal	Frontiers in immunology
Volume	9
Issue number	JAN
DOIs	https://doi.org/10.3389/fimmu.2017.02014
State	Published - Jan 31 2018

Bibliographical note

Publisher Copyright:
© 2018 Hippen, Loschi, Nicholls, MacDonald and Blazar.

Keywords

Graft-versus-host disease
ITreg
MicroRNA
Regulatory T cell
TTreg

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10.3389/fimmu.2017.02014

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797797

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title = "Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease",

abstract = "Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.",

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AU - Blazar, Bruce R.

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Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Abstract

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