Effects of phenytoin on cocaine self-administration in humans

Mehmet Sofuoglu, Paul R. Pentel, Robin L. Bliss, Anne I. Goldman, Dorothy K. Hatsukami

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The goal of this pilot study was to determine the effects of phenytoin on cocaine self-administration in a human laboratory model. Subjects were randomized to either phenytoin (n=6) or placebo (n=7). Those assigned to phenytoin treatment received a single oral loading dose of 20 mg/kg. The phenytoin and placebo treatment groups did not differ in the number of tokens, valued at $5, exchanged for cocaine. Similarly, the cardiovascular and subjective response to cocaine administration did not show a statistically significant treatment effect. In this laboratory model, phenytoin did not alter either the self-administration or effects of cocaine. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
JournalDrug and alcohol dependence
Volume53
Issue number3
DOIs
StatePublished - Feb 1 1999

Bibliographical note

Funding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank to David Babb, Susan Dudish-Poulsen, Micah Hammer and Daniella Jentzch for technical assistance, Dr Nina Graves for helpful discussion and the General Clinical Research Center nursing staff.

Keywords

  • Cocaine
  • Crack-cocaine
  • Oral loading
  • Phenytoin
  • Self-administration

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