Pinus massoniana Lamb is a Chinese red pine species used in traditional medicine for the treatment of a variety of human health disorders. Recent studies have shown that P. massoniana bark extract (PMBE) has an anti-proliferation effect on cancer cells. However, it is not clear if PMBE affects cancer cell migration and/or invasion. We tested the effect of PMBE, which has B-type procyanidin as its main constituent, on the adhesion and migration capabilities of HeLa cells, a human cervical cancer cell line, cultured in vitro. Our results showed that PMBE has no significant effect on the adhesion capability of HeLa cells, but strongly inhibits their migration. This finding suggests that PMBE could be a potential therapeutic agent for metastatic cancer.
Bibliographical noteFunding Information:
This work was supported by the Innovative Activity Project Grant for University Student of Shanghai City, China to Wu DC and Li S (No. 2008-TJ-057 ). We wish to express our gratitude to Professor Guangtao Yao of Shanghai University of Traditional Chinese Medicine and Professor Jun Zhang, technician Hongjun Shi of our medical school for their sincere help during our experiments. We also thank Professor Peter Grigg of the University of Massachusetts Medical School for his critical reading of the manuscript and the reviewers for their helpful comments.
- Cell adhesion
- Cell migration
- HeLa cells
- Pinus massoniana bark extract (PMBE)