Effects of pulsatile perfusion on the immunogenicity of renal allografts

William D. Payne, Lester D. Michels, Luis H. Toledo-Pereyra, Richard L. Simmons, John S. Najarian

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The results in 190 consecutive perfused cadaver renal transplants failed to show a detrimental effect of long-term perfusion. In a controlled study in mongrel dogs, those receiving transplants preserved by pulsatile perfusion for 24 or 48 hr had equal or better survival than those receiving grafts preserved by cold storage or unpreserved grafts. In addition, kidneys preserved for 24 hr by perfusion showed functional abnormalities similar to those preserved as long by cold storage and those transplanted as fresh grafts. It can be concluded that pulsatile perfusion as a means of preservation does not adversely affect long-term function and does not increase the effective immunogenicity of renal allografts.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalJournal of Surgical Research
Volume22
Issue number4
DOIs
StatePublished - Apr 1977

Bibliographical note

Funding Information:
I Supported by USPHS Grants AM 13083 and Al 12754. W.D.P. is supported by NIH Fellowship 5 F32 Al 05281-02. Address reprint requests to Dr. Payne, Box 304, Mayo Memorial Building, 420 Delaware Street S.E., University of Minnesota Hospitals, Minneapolis, Minn. 55455.

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