Effects of Quorum Sensing on flaA Transcription and Autoagglutination in Campylobacter jejuni

Byeonghwa Jeon, Kikuji Itoh, Naoaki Misawa, Sangryeol Ryu

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Some bacteria can communicate with other species of bacteria by means of autoinducer-2 (AI-2)-mediated quorum sensing. In this study, we demonstrated that AI-2-mediated quorum sensing influences the transcription of flaA, the major flagellin gene in Campylobacterjejuni. A null mutation of luxS in C. jejuni strain 81116 reduced flaA transcription (approximately 43% that of the wild-type) and induced a reduction in motility. However, the luxS mutant had the same level of total flagellin protein as the wild-type. Transmission electron microscopy showed that the flagellar structure was preserved in the luxS mutant. The agglutination capability was reduced in the mutant strain, implying that quorum sensing might be involved in the formation of surface structures of C. jejuni. These observations suggest that AI-2-mediated quorum sensing may play a role in regulation of motility and surface properties in C. jejuni.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalMicrobiology and Immunology
Volume47
Issue number11
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Autoagglutination
  • Campylobacterjejuni
  • Flagellin expression
  • Quorum sensing

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