Material testing techniques were used to characterize the mechanical properties of corneal tissue and to observe the effects of corneal storage and growth factors on these properties. Uniaxial stress-relaxation tests were performed on fresh and stored rabbit corneas. Fresh corneas recovered an average of 37.7% of first-pull stress while those stored in MK solution recovered an average of 76%. Stress-relaxation time constants were also found to be significantly different. Uniaxial tensile tests of fresh monkey corneas were performed to evaluate wound strengths of penetrating incisions treated with platelet derived growth factor (PDGF). Treated wounds demonstrated a greater failure strength than untreated wounds, indicating that corneal healing is enhanced in the presence of PDGF. Mechanical testing of corneal tissue is thus shown to be a useful technique for investigating changes in corneal structure.
|Original language||English (US)|
|Title of host publication||Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|Number of pages||3|
|ISBN (Electronic)||0780309766, 9780780309760|
|State||Published - 1993|
|Event||12th Southern Biomedical Engineering Conference, SBEC 1993 - New Orleans, United States|
Duration: Apr 2 1993 → Apr 4 1993
|Name||Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993|
|Conference||12th Southern Biomedical Engineering Conference, SBEC 1993|
|Period||4/2/93 → 4/4/93|
Bibliographical noteFunding Information:
This work was supported in part by National Institutes of Health Research Grants EY-04074 and EY-02377.
© 1993 IEEE.