Effects of storage and wound healing on corneal biomechanics

J. C. Coleman; R. W. Beuerman; S. Kaufman; D. A. Rice

doi:10.1109/SBEC.1993.247392

Effects of storage and wound healing on corneal biomechanics

J. C. Coleman, R. W. Beuerman, S. Kaufman, D. A. Rice

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Material testing techniques were used to characterize the mechanical properties of corneal tissue and to observe the effects of corneal storage and growth factors on these properties. Uniaxial stress-relaxation tests were performed on fresh and stored rabbit corneas. Fresh corneas recovered an average of 37.7% of first-pull stress while those stored in MK solution recovered an average of 76%. Stress-relaxation time constants were also found to be significantly different. Uniaxial tensile tests of fresh monkey corneas were performed to evaluate wound strengths of penetrating incisions treated with platelet derived growth factor (PDGF). Treated wounds demonstrated a greater failure strength than untreated wounds, indicating that corneal healing is enhanced in the presence of PDGF. Mechanical testing of corneal tissue is thus shown to be a useful technique for investigating changes in corneal structure.

Original language	English (US)
Title of host publication	Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	147-149
Number of pages	3
ISBN (Electronic)	0780309766, 9780780309760
DOIs	https://doi.org/10.1109/SBEC.1993.247392
State	Published - 1993
Externally published	Yes
Event	12th Southern Biomedical Engineering Conference, SBEC 1993 - New Orleans, United States Duration: Apr 2 1993 → Apr 4 1993

Publication series

Name	Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993

Conference

Conference	12th Southern Biomedical Engineering Conference, SBEC 1993
Country/Territory	United States
City	New Orleans
Period	4/2/93 → 4/4/93

Bibliographical note

Funding Information:
This work was supported in part by National Institutes of Health Research Grants EY-04074 and EY-02377.

Publisher Copyright:
© 1993 IEEE.

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10.1109/SBEC.1993.247392

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Coleman, J. C., Beuerman, R. W., Kaufman, S., & Rice, D. A. (1993). Effects of storage and wound healing on corneal biomechanics. In Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993 (pp. 147-149). Article 247392 (Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SBEC.1993.247392

Effects of storage and wound healing on corneal biomechanics. / Coleman, J. C.; Beuerman, R. W.; Kaufman, S. et al.
Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993. Institute of Electrical and Electronics Engineers Inc., 1993. p. 147-149 247392 (Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Coleman, JC, Beuerman, RW, Kaufman, S & Rice, DA 1993, Effects of storage and wound healing on corneal biomechanics. in Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993., 247392, Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993, Institute of Electrical and Electronics Engineers Inc., pp. 147-149, 12th Southern Biomedical Engineering Conference, SBEC 1993, New Orleans, United States, 4/2/93. https://doi.org/10.1109/SBEC.1993.247392

Coleman JC, Beuerman RW, Kaufman S, Rice DA. Effects of storage and wound healing on corneal biomechanics. In Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993. Institute of Electrical and Electronics Engineers Inc. 1993. p. 147-149. 247392. (Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993). doi: 10.1109/SBEC.1993.247392

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abstract = "Material testing techniques were used to characterize the mechanical properties of corneal tissue and to observe the effects of corneal storage and growth factors on these properties. Uniaxial stress-relaxation tests were performed on fresh and stored rabbit corneas. Fresh corneas recovered an average of 37.7% of first-pull stress while those stored in MK solution recovered an average of 76%. Stress-relaxation time constants were also found to be significantly different. Uniaxial tensile tests of fresh monkey corneas were performed to evaluate wound strengths of penetrating incisions treated with platelet derived growth factor (PDGF). Treated wounds demonstrated a greater failure strength than untreated wounds, indicating that corneal healing is enhanced in the presence of PDGF. Mechanical testing of corneal tissue is thus shown to be a useful technique for investigating changes in corneal structure.",

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Effects of storage and wound healing on corneal biomechanics

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