TY - JOUR
T1 - Effects of systemic delivery of insulin on plasma lipids and lipoprotein concentrations in pancreas transplant recipients
AU - Katz, H. H.
AU - Nguyen, T. T.
AU - Velosa, J. A.
AU - Robertson, R. P.
AU - Rizza, R. A.
PY - 1994
Y1 - 1994
N2 - Objective: To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. Design: We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney recipients without diabetes who received the same immunosuppressive agents, and eight normal subjects. Material and Methods: In the three study groups, fasting and postprandial plasma glucose, insulin, C- peptide, cholesterol, triglyceride, free fatty acid, and apolipoprotein A-I, A-II, C-II, and C-III concentrations were determined. Results: Fasting and postprandial glucose concentrations did not differ between the two transplant groups; however, peripheral insulin concentrations were twice as high (P<0.05) in the pancreas-kidney recipients as in the kidney recipients both before (102 ± 15 versus 53 ± 6 pmol/L) and after (123 ± 22 versus 61 ± 6 nmol/L per 6 hours) ingestion of a meal. Preprandial and postprandial insulin levels in both transplant groups also were greater (P<0.5) than those in normal subjects (35 ± 6 pmol/L and 40 ± 7 nmol/L per 6 hours, respectively). Despite significant differences in insulin concentrations, no differences were noted in total cholesterol, high-density or low-density lipoprotein cholesterol, plasma free fatty acids, or apolipoprotein A-I, A- II, C-II, and C-III concentrations among the study groups. Plasma triglyceride concentrations in the two transplant groups were similar (114 ± 20 versus 142 ± 18 mg/dL) and were slightly more than those in the normal subjects (80 ± 7 mg/dL). Conclusion: Despite peripheral hyperinsulinemia, pancreas transplantation can result in normal or near-normal lipid and lipoprotein concentrations. Thus, systemic delivery of insulin does not invariably produce an atherogenic lipid profile.
AB - Objective: To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. Design: We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney recipients without diabetes who received the same immunosuppressive agents, and eight normal subjects. Material and Methods: In the three study groups, fasting and postprandial plasma glucose, insulin, C- peptide, cholesterol, triglyceride, free fatty acid, and apolipoprotein A-I, A-II, C-II, and C-III concentrations were determined. Results: Fasting and postprandial glucose concentrations did not differ between the two transplant groups; however, peripheral insulin concentrations were twice as high (P<0.05) in the pancreas-kidney recipients as in the kidney recipients both before (102 ± 15 versus 53 ± 6 pmol/L) and after (123 ± 22 versus 61 ± 6 nmol/L per 6 hours) ingestion of a meal. Preprandial and postprandial insulin levels in both transplant groups also were greater (P<0.5) than those in normal subjects (35 ± 6 pmol/L and 40 ± 7 nmol/L per 6 hours, respectively). Despite significant differences in insulin concentrations, no differences were noted in total cholesterol, high-density or low-density lipoprotein cholesterol, plasma free fatty acids, or apolipoprotein A-I, A- II, C-II, and C-III concentrations among the study groups. Plasma triglyceride concentrations in the two transplant groups were similar (114 ± 20 versus 142 ± 18 mg/dL) and were slightly more than those in the normal subjects (80 ± 7 mg/dL). Conclusion: Despite peripheral hyperinsulinemia, pancreas transplantation can result in normal or near-normal lipid and lipoprotein concentrations. Thus, systemic delivery of insulin does not invariably produce an atherogenic lipid profile.
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M3 - Article
C2 - 8133660
AN - SCOPUS:0028281687
SN - 0025-6196
VL - 69
SP - 231
EP - 236
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 3
ER -