Effects of xylitol on gastric emptying and food intake

R. B. Shafer, A. S. Levine, J. M. Marlette, J. E. Morley

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


We studied the effects of xylitol, the pentose-sugar alcohol, on gastric emptying of the solid-food component of a complex meal. Gastric emptying was measured in human volunteers by utilizing a standardized radiolabeled scrambled-egg meal. After ingestion of 25 g xylitol, gastric emptying was markedly prolonged (T- 1/2 58 ± 5 min control vs 91 ± 7 min after xylitol [P < 0.01]). Since delayed gastric emptying may affect food intake, we evaluated the effects of xylitol on calorie intake. Food intake after oral preloading with water resulted in intake of 920 ± 60 kcal vs 690 ± 45 kcal after 25 g of xylitol. In contrast, a preload of glucose, fructose, or sucrose failed to suppress food intake. Although xylitol decreased food intake and also delayed gastric emptying, these effects may be unrelated. Our data suggest a role for xylitol as a potentially important agent in dietary control.

Original languageEnglish (US)
Pages (from-to)744-747
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - Jan 1 1987


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