Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia

Brian J. Roach, Judith M. Ford, Bruno Biagianti, Holly K. Hamilton, Ian S. Ramsay, Melissa Fisher, Rachel Loewy, Sophia Vinogradov, Daniel H. Mathalon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: During vocalization, efference copy/corollary discharge mechanisms suppress the auditory cortical response to self-generated sounds as reflected in the N1 component of the auditory event-related potential (ERP). N1 suppression during talking is reduced in patients with schizophrenia. We hypothesized that these deficits would recover with auditory training that targets the speech processing system. Methods: Forty-nine individuals early in the course of a schizophrenia-spectrum illness (ESZ) were randomly assigned to 40 h of Targeted Auditory Training (TAT; n = 23) or Computer Games (CG; n = 26). The N1 ERP component was elicited during production (Talk) and playback (Listen) of vocalization. Effects of Treatment on Global Cognition, N1 suppression (Talk-Listen), N1 during Talking and Listening were assessed. Simple effects of the passage of time were also assessed in the HC after 28 weeks. Results: There was a Treatment × Time interaction revealing that N1 suppression was improved with TAT, but not with CG. TAT, but not CG, also improved Global Cognition. However, TAT and CG groups differed in their pre-treatment N1 suppression, and greater N1-suppression abnormalities were strongly associated with greater improvement in N1 suppression. Conclusions: In this sample of ESZ individuals, targeted auditory training appeared to improve the function of the efference copy/corollary discharge mechanism which tended to deteriorate with computer games. It remains to be determined if baseline N1 suppression abnormalities are necessary for TAT treatment to have a positive effect on efference copy/corollary discharge function or if improvements observed in this study represent a regression to the mean N1 suppression in ESZ. Trial registration: ClinicalTrials.gov NCT00694889. Registered 1 August 2007.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalInternational Journal of Psychophysiology
Volume145
DOIs
StatePublished - Nov 2019

Bibliographical note

Funding Information:
This study was supported by the National Institute of Mental Health under Award Numbers K02MH067967 (PI: JMF), R01MH058262 (PI: JMF), 5R01MH081051 (PI: SV), R01MH076898 (PI: DHM); by the Stanley Medical Research Institute under Award Number 06TAF-972 (PI: SV), by the Department of Veterans Affairs (PIs: SV, JMF, and a Senior Research Career Scientist award to JMF), and by the Brain and Behavior Research Foundation (PI: DHM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

Funding Information:
This study was supported by the National Institute of Mental Health under Award Numbers K02MH067967 (PI: JMF), R01MH058262 (PI: JMF), 5R01MH081051 (PI: SV), R01MH076898 (PI: DHM); by the Stanley Medical Research Institute under Award Number 06TAF-972 (PI: SV), by the Department of Veterans Affairs (PIs: SV, JMF, and a Senior Research Career Scientist award to JMF), and by the Brain and Behavior Research Foundation (PI: DHM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

Funding Information:
At the time of study completion, BB was a post-doctoral research fellow partially funded by Posit Science. The auditory training software used in this study was supplied free of charge by Posit Science. SV is a site PI on an SBIR grant to Posit Science, a company with a commercial interest in the training software used in these studies. None of the other authors have any financial interest in Posit Science. All authors declare no other conflicts of interest.

Publisher Copyright:
© 2019 Elsevier B.V.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Auditory ERP
  • Cognitive training
  • Efference copy/corollary discharge
  • Schizophrenia

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