Abstract
The direct alkynylation of tautomerizable heterocylcles is described via a two-step process involving in situ C-OH activation with bromotripyrrolidinophosphonium hexafluorophosphate (PyBrOP) followed by Sonogashira coupling with a wide range of alkyl or aryl terminal alkynes using a copper-free system employing PdCl2(CH3CN)2 and 2-(dicyclohexylphosphino)biphenyl.
Original language | English (US) |
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Pages (from-to) | 2286-2289 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 10 |
DOIs | |
State | Published - May 21 2010 |