Efficient preparation of aminoxyacyl amides, aminoxy hybrid peptides, and α-aminoxy peptides

Alan R. Katritzky, Ilker Avan, Srinivasa R. Tala

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

(Chemical Equation Presented) N-(Pg-α-aminoxy acids) 1a-g are converted to N-(Pg-α-aminoxyacyl)benzotriazoles 2a-g, which react under mild conditions with amines, α-amino acids/α-dipeptides, and α-aminoxy acids to give aminoxyacyl amides 3a-g, (3e+3e′), and (3g+3g′), aminoxy hybrid peptides 4a-h, (4a+4a′), 6a-d, 9a-e, (9a+9a′), and (9b+9b′), and α-aminoxy peptides 10a,b in good yields without racemization.

Original languageEnglish (US)
Pages (from-to)8690-8694
Number of pages5
JournalJournal of Organic Chemistry
Volume74
Issue number22
DOIs
StatePublished - Nov 20 2009

Fingerprint Dive into the research topics of 'Efficient preparation of aminoxyacyl amides, aminoxy hybrid peptides, and α-aminoxy peptides'. Together they form a unique fingerprint.

Cite this