Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease

Tanya R. Flohr; Hugo Bonatti; Tjasa Hranjec; Doug S. Keith; Peter I. Lobo; Sean C. Kumer; Timothy M. Schmitt; Robert G. Sawyer; Timothy L. Pruett; John P. Roberts; Kenneth L. Brayman

doi:10.1016/j.jss.2011.10.028

Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease

Tanya R. Flohr, Hugo Bonatti, Tjasa Hranjec, Doug S. Keith, Peter I. Lobo, Sean C. Kumer, Timothy M. Schmitt, Robert G. Sawyer, Timothy L. Pruett, John P. Roberts, Kenneth L. Brayman

Surgery

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.

Original language	English (US)
Pages (from-to)	629-638
Number of pages	10
Journal	Journal of Surgical Research
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/j.jss.2011.10.028
State	Published - Aug 2012

Bibliographical note

Funding Information:
This work was supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Keywords

HCV
elderly
end-stage renal disease
hepatitis C
infectious diseases
kidney transplant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{908dd71aebd043f8a9e0b061eea4fec8,

title = "Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease",

abstract = "Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.",

keywords = "HCV, elderly, end-stage renal disease, hepatitis C, infectious diseases, kidney transplant",

author = "Flohr, {Tanya R.} and Hugo Bonatti and Tjasa Hranjec and Keith, {Doug S.} and Lobo, {Peter I.} and Kumer, {Sean C.} and Schmitt, {Timothy M.} and Sawyer, {Robert G.} and Pruett, {Timothy L.} and Roberts, {John P.} and Brayman, {Kenneth L.}",

note = "Funding Information: This work was supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. ",

year = "2012",

month = aug,

doi = "10.1016/j.jss.2011.10.028",

language = "English (US)",

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T1 - Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease

AU - Flohr, Tanya R.

AU - Bonatti, Hugo

AU - Hranjec, Tjasa

AU - Keith, Doug S.

AU - Lobo, Peter I.

AU - Kumer, Sean C.

AU - Schmitt, Timothy M.

AU - Sawyer, Robert G.

AU - Pruett, Timothy L.

AU - Roberts, John P.

AU - Brayman, Kenneth L.

N1 - Funding Information: This work was supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

PY - 2012/8

Y1 - 2012/8

N2 - Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.

AB - Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.

KW - HCV

KW - elderly

KW - end-stage renal disease

KW - hepatitis C

KW - infectious diseases

KW - kidney transplant

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ER -

Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease

Abstract

Bibliographical note

Keywords

UN SDGs

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