TY - JOUR
T1 - Electroconvulsive therapy for depression in Parkinson's disease
T2 - systematic review of evidence and recommendations
AU - Borisovskaya, Anna
AU - Bryson, William Culbertson
AU - Buchholz, Jonathan
AU - Samii, Ali
AU - Borson, Soo
PY - 2016/4/1
Y1 - 2016/4/1
N2 - AIM: We performed a systematic review of evidence regarding treatment of depression in Parkinson's disease (PD) utilizing electroconvulsive therapy.METHODS: The search led to the inclusion of 43 articles, mainly case reports or case series, with the largest number of patients totaling 19.RESULTS: The analysis included 116 patients with depression and PD; depression improved in 93.1%. Where motor symptoms' severity was reported, 83% of patients improved. Cognition did not worsen in the majority (94%). Many patients experienced delirium or transient confusion, sometimes necessitating discontinuation of electroconvulsive therapy (ECT). Little is known about maintenance ECT in this population.CONCLUSION: ECT can benefit patients suffering from PD and depression. We recommend an algorithm for treatment of depression in PD, utilizing ECT sooner rather than later.
AB - AIM: We performed a systematic review of evidence regarding treatment of depression in Parkinson's disease (PD) utilizing electroconvulsive therapy.METHODS: The search led to the inclusion of 43 articles, mainly case reports or case series, with the largest number of patients totaling 19.RESULTS: The analysis included 116 patients with depression and PD; depression improved in 93.1%. Where motor symptoms' severity was reported, 83% of patients improved. Cognition did not worsen in the majority (94%). Many patients experienced delirium or transient confusion, sometimes necessitating discontinuation of electroconvulsive therapy (ECT). Little is known about maintenance ECT in this population.CONCLUSION: ECT can benefit patients suffering from PD and depression. We recommend an algorithm for treatment of depression in PD, utilizing ECT sooner rather than later.
KW - electroconvulsive therapy
KW - major depressive disorder
KW - Parkinson's disease
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U2 - 10.2217/nmt-2016-0002
DO - 10.2217/nmt-2016-0002
M3 - Review article
C2 - 27033556
SN - 1758-2024
VL - 6
SP - 161
EP - 176
JO - Neurodegenerative disease management
JF - Neurodegenerative disease management
IS - 2
ER -