Research into the relationship between dietary electrolytes and the primary cause and treatment of hypertension has now reached the stage where long-term, detailed, controlled, randomized, clinical trials of intervention need to be carried out among those at high risk, including children. Such trials must incorporate methods for estimating "sensitive" responders. The designs should also include precise measures of change in dietary electrolyte intake and allow for analysis of interaction of the effects of individual electrolytes. We have sketched the unforeseen errors, that now must be avoided, from earlier studies and given an outline of a current study that sets out to meet optimum requirements. It is to be hoped that many similar studies will soon be initiated in multiple population groups.
Bibliographical noteFunding Information:
This work was supported in part by grants HL34659-01 and HL19877-09 from the U.S. National Heart Lung and Blood Institute.
Recently the role of nutrition in the regulation of blood pressure and the pathogenesis of hypertension was considered a t a workshop i n Bethesda sponsored by the U.S. National Heart Lung and Blood Institute, the National Institute on Aging and the National Ins ti tutes of Health Nutrition Coordinating Committee (3). The clinicians and basic scien-tists studying those problems made a number of recommendations and posed a series of questions for future research. Among these was:
- Intervention programme