Electrophysiological Study of the Gustatory Effects of the Sweet Proteins Monellin and Thaumatin in Monkey, Guinea Pig and Rat

J. N. Brouwer, G. Hellekant, Y. Kasahara, H. van der Wel, Y. Zotterman

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Abstract

The afferent activity of the facial portion of the chorda‐lingual nerve, the chorda tympani proper, and the glossopharyngeal nerves was recorded during the application of 0.02 % and 0.005 % solutions of Monellin (2times 10‐5 and 5times 10‐6 M) and Thaumatin (10‐5 and 2.1) × 10 ‐6 M) and of 0.5 M sucrose, 0.3 M NaCl and 0.03 M citric acid, representing the three taste qualities sweet, salt and acid. Monellin and Thaumatin, which give a sweet sensation in man, elicited a significant electrophysiological response in the monkey which showed several characteristics that could be related to psychophysical observations in man. In guinea pig and rat little or no response could be recorded.

Original languageEnglish (US)
Pages (from-to)550-557
Number of pages8
JournalActa Physiologica Scandinavica
Volume89
Issue number4
DOIs
StatePublished - Dec 1973

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