Electroporation ablative therapy as a clinical tool: An old technology revisited

Lars M. Mattison, Brian T. Howard, Paul A. Iaizzo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Electroporation is considered a novel means for treating tissue using high-voltage, short-duration direct current (DC) pulses to elicit different cellular responses. Varying the parameters of the therapeutic pulses allows for either temporary or permanent cellular damage. It is believed that applied DC pulses disrupt cell membranes, with larger electric fields causing more damage. A wide variety of input parameters allows for the ability to fine tune this technology to target different tissue types. Since the delivery of energy is based on an electric field compared to a thermal field, there is also potential to better target specific areas while minimizing collateral tissue damage. The ability to apply electroporation therapy, in its latest technological form, is currently being explored to understand its possible clinical applications.

Original languageEnglish (US)
Title of host publicationEngineering in Medicine
Subtitle of host publicationAdvances and Challenges
PublisherElsevier
Pages179-200
Number of pages22
ISBN (Electronic)9780128130681
ISBN (Print)9780128135143
DOIs
StatePublished - Jan 1 2018

Keywords

  • Ablation technology
  • Catheter ablation
  • Electrochemotherapy
  • Electroporation
  • Irreversible electroporation
  • Surgical ablation

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