Abstract
Complementary electrostatic interactions between negatively charged B-DNA and a positively charged array on the λ Cro repressor protein are shown to substantially contribute to the formation energy of sequence-specific and nonspecific Cro-DNA complexes. The electrostatic interactions favor Cro binding to a bent form of DNA, a geometry which optimizes hydrogen-bonding contacts between Cro and exposed base pair groups in the DNA major groove.
Original language | English (US) |
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Pages (from-to) | 5860-5862 |
Number of pages | 3 |
Journal | Journal of Biological Chemistry |
Volume | 260 |
Issue number | 10 |
State | Published - 1985 |