TY - JOUR
T1 - Elevated Levels of Adhesion Proteins Are Associated with Low Ankle-Brachial Index
T2 - Multi-Ethnic Study of Atherosclerosis
AU - Berardi, Cecilia
AU - Wassel, Christine L.
AU - Decker, Paul A.
AU - Larson, Nicholas B.
AU - Kirsch, Phillip S.
AU - Andrade, Mariza De
AU - Tsai, Michael Y.
AU - Pankow, James S.
AU - Sale, Michele M.
AU - Sicotte, Hugues
AU - Tang, Weihong
AU - Hanson, Naomi Q.
AU - McDermott, Mary M.
AU - Criqui, Michael H.
AU - Allison, Michael A.
AU - Bielinski, Suzette J.
N1 - Publisher Copyright:
© SAGE Publications.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Inflammation plays a pivotal role in peripheral artery disease (PAD). Cellular adhesion proteins mediate the interaction of leukocytes with endothelial cells during inflammation. To determine the association of cellular adhesion molecules with ankle-brachial index (ABI) and ABI category (≤1.0 vs >1.0) in a diverse population, 15 adhesion proteins were measured in the Multi-Ethnic Study of Atherosclerosis (MESA). To assess multivariable associations of each protein with ABI and ABI category, linear and logistic regression was used, respectively. Among 2364 participants, 23 presented with poorly compressible arteries (ABI > 1.4) and were excluded and 261 had ABI ≤ 1.0. Adjusting for traditional risk factors, elevated levels of soluble P-selectin, hepatocyte growth factor, and secretory leukocyte protease inhibitor were associated with lower ABI (P =.0004,.001, and.002, respectively). Per each standard deviation of protein, we found 26%, 20%, and 19% greater odds of lower ABI category (P =.001,.01, and.02, respectively). Further investigation into the adhesion pathway may shed new light on biological mechanisms implicated in PAD.
AB - Inflammation plays a pivotal role in peripheral artery disease (PAD). Cellular adhesion proteins mediate the interaction of leukocytes with endothelial cells during inflammation. To determine the association of cellular adhesion molecules with ankle-brachial index (ABI) and ABI category (≤1.0 vs >1.0) in a diverse population, 15 adhesion proteins were measured in the Multi-Ethnic Study of Atherosclerosis (MESA). To assess multivariable associations of each protein with ABI and ABI category, linear and logistic regression was used, respectively. Among 2364 participants, 23 presented with poorly compressible arteries (ABI > 1.4) and were excluded and 261 had ABI ≤ 1.0. Adjusting for traditional risk factors, elevated levels of soluble P-selectin, hepatocyte growth factor, and secretory leukocyte protease inhibitor were associated with lower ABI (P =.0004,.001, and.002, respectively). Per each standard deviation of protein, we found 26%, 20%, and 19% greater odds of lower ABI category (P =.001,.01, and.02, respectively). Further investigation into the adhesion pathway may shed new light on biological mechanisms implicated in PAD.
KW - P-selectin
KW - ankle-brachial index
KW - hepatocyte growth factor
KW - peripheral artery disease
KW - secretory leukocyte protease inhibitor
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U2 - 10.1177/0003319716659178
DO - 10.1177/0003319716659178
M3 - Article
C2 - 27436494
AN - SCOPUS:85016090007
SN - 0003-3197
VL - 68
SP - 322
EP - 329
JO - Angiology
JF - Angiology
IS - 4
ER -
