ELEVATED PLASMA PHENYLALANINE CONCENTRATION AND LYSINE INCORPORATION INTO RIBOSOMAL PROTEIN OF DEVELOPING BRAIN

Kenneth F Swaiman, W. B. Hosfield, B. Lemieux

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Hyperphenylalaninemia was induced in 7‐day‐old rabbits over a 6‐hr period by intraperitoneal injection of phenylalanine. l‐[U‐14C]Lysine was injected intraperitoneally into these rabbits and into a control group. The rate of incorporation of l‐[U‐14C]lysme into brain ribosomal protein was decreased during a 5‐hr period in the presence of elevated plasma phenylalanine concentrations. Lysine transport from the peritoneum to the plasma was unaffected by the high plasma phenylalanine concentrations.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalJournal of Neurochemistry
Volume15
Issue number7
DOIs
StatePublished - Jun 1968

Fingerprint

Dive into the research topics of 'ELEVATED PLASMA PHENYLALANINE CONCENTRATION AND LYSINE INCORPORATION INTO RIBOSOMAL PROTEIN OF DEVELOPING BRAIN'. Together they form a unique fingerprint.

Cite this