Emerging Systemic Therapies for the Management of Penile Cancer

Shilpa Gupta; Guru Sonpavde

doi:10.1016/j.ucl.2016.06.009

Emerging Systemic Therapies for the Management of Penile Cancer

Shilpa Gupta, Guru Sonpavde

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC.

Original language	English (US)
Pages (from-to)	481-491
Number of pages	11
Journal	Urologic Clinics of North America
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.ucl.2016.06.009
State	Published - Nov 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Chemotherapy
Combined modality therapy
EGFR
PD-1
Penile squamous cell carcinoma
Targeted therapy
VEGF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.ucl.2016.06.009

OpenUrl availability

Full text

Cite this

@article{61040610666c4f6bb5e5c9815fb44ccc,

title = "Emerging Systemic Therapies for the Management of Penile Cancer",

abstract = "Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC.",

keywords = "Chemotherapy, Combined modality therapy, EGFR, PD-1, Penile squamous cell carcinoma, Targeted therapy, VEGF",

author = "Shilpa Gupta and Guru Sonpavde",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.ucl.2016.06.009",

language = "English (US)",

volume = "43",

pages = "481--491",

journal = "Urologic Clinics of North America",

issn = "0094-0143",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Emerging Systemic Therapies for the Management of Penile Cancer

AU - Gupta, Shilpa

AU - Sonpavde, Guru

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC.

AB - Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC.

KW - Chemotherapy

KW - Combined modality therapy

KW - EGFR

KW - PD-1

KW - Penile squamous cell carcinoma

KW - Targeted therapy

KW - VEGF

UR - http://www.scopus.com/inward/record.url?scp=84995484458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995484458&partnerID=8YFLogxK

U2 - 10.1016/j.ucl.2016.06.009

DO - 10.1016/j.ucl.2016.06.009

M3 - Review article

C2 - 27717434

AN - SCOPUS:84995484458

SN - 0094-0143

VL - 43

SP - 481

EP - 491

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 4

ER -

Emerging Systemic Therapies for the Management of Penile Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this