TY - JOUR
T1 - Emerging technologies in mechanotransduction research
AU - Shamsan, Ghaidan A.
AU - Odde, David J.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Mechanotransduction research focuses on understanding how cells sense and respond to mechanical stimuli by converting mechanical signals into biochemical and biological responses. Cells have been shown to respond to mechanical stimuli through specialized biological machinery such as adhesion complexes. Research in the last two decades helped in identifying key components of cellular mechanotransduction. In recent years, integrated approaches, which are highlighted here, are emerging to provide new insights into the mechanistic and theoretical underpinnings of mechanotransduction. In particular, mathematical modeling has helped elucidate the mechanism underlining ligand spacing and distribution sensing, as well as sensing viscoelastic properties of the extracellular matrix. In addition, molecular tension sensors have helped dissect the forces involved in mechanotransduction at high spatial and temporal resolutions.
AB - Mechanotransduction research focuses on understanding how cells sense and respond to mechanical stimuli by converting mechanical signals into biochemical and biological responses. Cells have been shown to respond to mechanical stimuli through specialized biological machinery such as adhesion complexes. Research in the last two decades helped in identifying key components of cellular mechanotransduction. In recent years, integrated approaches, which are highlighted here, are emerging to provide new insights into the mechanistic and theoretical underpinnings of mechanotransduction. In particular, mathematical modeling has helped elucidate the mechanism underlining ligand spacing and distribution sensing, as well as sensing viscoelastic properties of the extracellular matrix. In addition, molecular tension sensors have helped dissect the forces involved in mechanotransduction at high spatial and temporal resolutions.
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U2 - 10.1016/j.cbpa.2019.08.002
DO - 10.1016/j.cbpa.2019.08.002
M3 - Review article
C2 - 31618703
AN - SCOPUS:85073058267
SN - 1367-5931
VL - 53
SP - 125
EP - 130
JO - Current opinion in chemical biology
JF - Current opinion in chemical biology
ER -