Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation

Alice S. Chen-Plotkin; Keith A. Vossel; Martin A. Samuels; Ming Hui Chen

doi:10.1212/01.wnl.0000256716.04218.5b

Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation

Alice S. Chen-Plotkin, Keith A. Vossel, Martin A. Samuels, Ming Hui Chen

Neurology

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40 Scopus citations

Abstract

Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.

Original language	English (US)
Pages (from-to)	859-861
Number of pages	3
Journal	Neurology
Volume	68
Issue number	11
DOIs	https://doi.org/10.1212/01.wnl.0000256716.04218.5b
State	Published - Mar 2007

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abstract = "Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.",

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AB - Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.

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Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation

Abstract

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