Endogenous opiates and stress ulceration

John E. Morley; Allen S. Levine; Stephen E. Silvis

doi:10.1016/0024-3205(82)90771-8

Endogenous opiates and stress ulceration

John E. Morley, Allen S. Levine, Stephen E. Silvis

Medicine - Administration

Research output: Contribution to journal › Article › peer-review

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Abstract

Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.

Original language	English (US)
Pages (from-to)	693-699
Number of pages	7
Journal	Life Sciences
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(82)90771-8
State	Published - Aug 16 1982

Bibliographical note

Funding Information:
We thank Julie Knelp and Martha Grace for technical assistance and JoAnn Tallman for secretarial assistance. Research was supported by the Veterans Administration.

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title = "Endogenous opiates and stress ulceration",

abstract = "Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.",

author = "Morley, {John E.} and Levine, {Allen S.} and Silvis, {Stephen E.}",

note = "Funding Information: We thank Julie Knelp and Martha Grace for technical assistance and JoAnn Tallman for secretarial assistance. Research was supported by the Veterans Administration.",

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AU - Levine, Allen S.

AU - Silvis, Stephen E.

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N2 - Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.

AB - Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.

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Endogenous opiates and stress ulceration

Abstract

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