TY - JOUR
T1 - Endometrial stromal sarcoma with focal smooth muscle differentiation
T2 - Recurrence after 17 years: a follow-up report with discussion of the nomenclature
AU - Khalifa, Mahmoud A.
AU - Hansen, Christian H.
AU - Moore, James L.
AU - Rusnock, Eileen J.
AU - Lage, Janice M.
PY - 1996
Y1 - 1996
N2 - In 1977, a case report was published describing a 28-year-old woman with an endometrial stromal tumor that showed loci of myogenic differentiation. The term 'stromomyoma' was introduced to encompass both this type of neoplasm as well as 'uterine neoplasms resembling ovarian sexcord tumors' (UTROSCTs). More than 17 years later, the tumor recurred, involving the right ovary, sigmoid colon, small bowel, abdominal wall, and omentum. The histologic and electron microscopic similarities between the recurrent tumor and the primary neoplasm were confirmed. Applying the recent classification and diagnostic criteria of endometrial mesenchymal neoplasms, we have concluded that this tumor was a low-grade endometrial stromal sarcoma (LGSS). The formerly proposed term 'stromomyoma' implies a benign tumor, in contrast to the obviously malignant nature of this particular tumor. Focal myogenic differentiation of LGSS is not an uncommon finding and does not warrant a separate diagnostic or prognostic entity. UTROSCTs and endometrial stromal sarcomas are two separate diagnostic entities, and combining them under an inclusive terminology is not appropriate.
AB - In 1977, a case report was published describing a 28-year-old woman with an endometrial stromal tumor that showed loci of myogenic differentiation. The term 'stromomyoma' was introduced to encompass both this type of neoplasm as well as 'uterine neoplasms resembling ovarian sexcord tumors' (UTROSCTs). More than 17 years later, the tumor recurred, involving the right ovary, sigmoid colon, small bowel, abdominal wall, and omentum. The histologic and electron microscopic similarities between the recurrent tumor and the primary neoplasm were confirmed. Applying the recent classification and diagnostic criteria of endometrial mesenchymal neoplasms, we have concluded that this tumor was a low-grade endometrial stromal sarcoma (LGSS). The formerly proposed term 'stromomyoma' implies a benign tumor, in contrast to the obviously malignant nature of this particular tumor. Focal myogenic differentiation of LGSS is not an uncommon finding and does not warrant a separate diagnostic or prognostic entity. UTROSCTs and endometrial stromal sarcomas are two separate diagnostic entities, and combining them under an inclusive terminology is not appropriate.
KW - Endometrial neoplasm
KW - Endometrial stromal sarcoma
KW - Endometrium
KW - Sarcoma metastatic to ovary
KW - Stromomyoma
KW - Uterine sarcoma
KW - Uterine sex cord-like tumor
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U2 - 10.1097/00004347-199604000-00013
DO - 10.1097/00004347-199604000-00013
M3 - Article
C2 - 8786208
AN - SCOPUS:0029862910
SN - 0277-1691
VL - 15
SP - 171
EP - 176
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 2
ER -