Abstract
(Figure Presented) Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.
Original language | English (US) |
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Pages (from-to) | 357-363 |
Number of pages | 7 |
Journal | Biomacromolecules |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 12 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2014 American Chemical Society.