Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers

Jukuan Zheng, Dimitria Kontoveros, Fei Lin, Geng Hua, Darrell H. Reneker, Matthew L. Becker, Rebecca K. Willits

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

(Figure Presented) Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalBiomacromolecules
Volume16
Issue number1
DOIs
StatePublished - Jan 12 2015

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

Fingerprint

Dive into the research topics of 'Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers'. Together they form a unique fingerprint.

Cite this