TY - JOUR
T1 - Enhancer point mutation results in a homeotic transformation in drosophila
AU - Shimell, Mary Jane
AU - Simon, Jeffrey
AU - Bender, Welcome
AU - O'Connor, Michael B.
PY - 1994
Y1 - 1994
N2 - In Drosophila, the misexpression or altered activity of genes from the bithorax complex results in homeotic transformations. One of these genes, abd-A, normally specifies the identity of the second through fourth abdominal segments (A2 to A4). In the dominant Hyperabdominal mutations (Hab), portions of the third thoracic segment (T3) are transformed toward A2 as the result of ectopic abd-A expression. Sequence analysis and deoxyribonuclease I footprinting demonstrate that the misexpression of abd-A in two independent Hab mutations results from the same single base change in a binding site for the gap gene Krüppel protein. These results establish that the spatial limits of the homeotic genes are directly regulated by gap gene products.
AB - In Drosophila, the misexpression or altered activity of genes from the bithorax complex results in homeotic transformations. One of these genes, abd-A, normally specifies the identity of the second through fourth abdominal segments (A2 to A4). In the dominant Hyperabdominal mutations (Hab), portions of the third thoracic segment (T3) are transformed toward A2 as the result of ectopic abd-A expression. Sequence analysis and deoxyribonuclease I footprinting demonstrate that the misexpression of abd-A in two independent Hab mutations results from the same single base change in a binding site for the gap gene Krüppel protein. These results establish that the spatial limits of the homeotic genes are directly regulated by gap gene products.
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U2 - 10.1126/science.7909957
DO - 10.1126/science.7909957
M3 - Article
C2 - 7909957
AN - SCOPUS:0028179053
SN - 0036-8075
VL - 264
SP - 968
EP - 971
JO - Science
JF - Science
IS - 5161
ER -