Catalytic promiscuity - the ability of a single active site to catalyse more than one chemical transformation - has a natural role in evolution and occasionally in biosynthesis of secondary metabolites. Catalytic promiscuity is more widespread than often recognized. Recent success in adding and enhancing such catalytic activities by protein engineering suggests new potential applications in enzyme-catalyzed organic synthesis.
Bibliographical noteFunding Information:
I thank Krista Morley (McGill University) for the preparation of Figure 4 and the University of Minnesota for financial support.
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