Enigmatic roles of Mcm10 in DNA replication

Yee Mon Thu; Anja Katrin Bielinsky

doi:10.1016/j.tibs.2012.12.003

Enigmatic roles of Mcm10 in DNA replication

Yee Mon Thu, Anja Katrin Bielinsky

Molecular Biology (TMED)

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.

Original language	English (US)
Pages (from-to)	184-194
Number of pages	11
Journal	Trends in Biochemical Sciences
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.tibs.2012.12.003
State	Published - Apr 2013

Bibliographical note

Funding Information:
The authors wish to acknowledge funding from the National Institutes of Health (NIH) (GM074917) and the Leukemia and Lymphoma Society to A-K.B. and thank Dr Eric Hendrickson for proofreading of the manuscript.

Keywords

DNA replication
Double-strand breaks
Genome integrity
Mcm10
OB-fold
Replication forks
Zn-finger domains

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title = "Enigmatic roles of Mcm10 in DNA replication",

abstract = "Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.",

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N2 - Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.

AB - Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.

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KW - Double-strand breaks

KW - Genome integrity

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KW - OB-fold

KW - Replication forks

KW - Zn-finger domains

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Enigmatic roles of Mcm10 in DNA replication

Abstract

Bibliographical note

Keywords

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