Entamoeba histolytica infection in humans, chimpanzees and baboons in the Greater Gombe Ecosystem, Tanzania

Jessica R. Deere, Michele B. Parsons, Elizabeth V. Lonsdorf, Iddi Lipende, Shadrack Kamenya, D. Anthony Collins, Dominic A. Travis, Thomas R. Gillespie

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Entamoeba histolytica is an enteric parasite that infects approximately 50 million people worldwide. Although E. histolytica is a zoonotic parasite that has the potential to infect nonhuman primates, such transmission is poorly understood. Consequently, this study examined whether E. histolytica is present among humans, chimpanzees and baboons living in the Greater Gombe Ecosystem (GGE), Tanzania. The primary aims were to determine patterns of E. histolytica infection in a system with human-nonhuman primate overlap and to test associations between infection status and potential risk factors of disease. Entamoeba spp. occurred in 60.3% of human, 65.6% of chimpanzee and 88.6% of baboon samples. Entamoeba histolytica occurred in 12.1% of human, 34.1% of chimpanzee and 10.9% of baboon samples. Human E. histolytica infection was associated with gastrointestinal symptoms. This was the first study to confirm the presence of E. histolytica in the GGE. The high sample prevalence of E. histolytica in three sympatric primates suggests that zoonotic transmission is possible and stresses the need for further phylogenetic studies. Interventions targeting better sanitation and hygiene practices for humans living in the GGE can help prevent E. histolytica infection in humans, while also protecting the endangered chimpanzees and other primates in this region.

Original languageEnglish (US)
Pages (from-to)1116-1122
Number of pages7
JournalParasitology
Volume146
Issue number9
DOIs
StatePublished - Aug 1 2019

Bibliographical note

Funding Information:
This work was supported by the Morris Animal Foundation (MAF D09ZO-041 and MAF D09ZO-634), the Emory University Global Health Institute, the Arcus Foundation, the Leo S. Guthman Fund, and the National Institutes of Health (R01 AI58715).

Publisher Copyright:
© Copyright Cambridge University Press 2018.

Keywords

  • Amebiasis
  • diarrhoea
  • primates
  • protozoa
  • wildlife disease

Fingerprint

Dive into the research topics of 'Entamoeba histolytica infection in humans, chimpanzees and baboons in the Greater Gombe Ecosystem, Tanzania'. Together they form a unique fingerprint.

Cite this