TY - JOUR
T1 - Enterovirulence of Enterotoxigenic Bacteroides fragilis in Gnotobiotic Pigs
AU - Duimstra, J. R.
AU - Myers, L. L.
AU - Collins, Jim
AU - Benfield, D. A.
AU - Shoop, D. S.
AU - Bradbury, W. C.
PY - 1991/11
Y1 - 1991/11
N2 - A porcine isolate of enterotoxigenic Bacteroides fragilis colonized the intestinal tract and caused watery, nonhemorrhagic diarrhea when given orally to 12, 1- to 2-day-old gnotobiotic pigs. Diarrhea occurred 2 to 3 days post-inoculation and continued throughout the 4 to 6 day post-inoculation period. Diarrheic pigs became mildly anorexic and dehydrated. They developed intestinal lesions characterized by swelling, vacuolation, and exfoliation of enterocytes, and crypt hyperplasia throughout the large intestine and, to a lesser extent, in the distal small intestine. Bacterial adherence to, or invasion of, the intestinal mucosa was not detected. A porcine isolate of nonenterotoxigenic B. fragilis was administered orally to six control pigs. The isolate colonized the intestinal tract, but the pigs did not develop clinical disease or intestinal lesions. The pathogenetic mechanism of the disease may involve mediation by a soluble enterotoxin (or toxins) elaborated by B. fragilis.
AB - A porcine isolate of enterotoxigenic Bacteroides fragilis colonized the intestinal tract and caused watery, nonhemorrhagic diarrhea when given orally to 12, 1- to 2-day-old gnotobiotic pigs. Diarrhea occurred 2 to 3 days post-inoculation and continued throughout the 4 to 6 day post-inoculation period. Diarrheic pigs became mildly anorexic and dehydrated. They developed intestinal lesions characterized by swelling, vacuolation, and exfoliation of enterocytes, and crypt hyperplasia throughout the large intestine and, to a lesser extent, in the distal small intestine. Bacterial adherence to, or invasion of, the intestinal mucosa was not detected. A porcine isolate of nonenterotoxigenic B. fragilis was administered orally to six control pigs. The isolate colonized the intestinal tract, but the pigs did not develop clinical disease or intestinal lesions. The pathogenetic mechanism of the disease may involve mediation by a soluble enterotoxin (or toxins) elaborated by B. fragilis.
UR - http://www.scopus.com/inward/record.url?scp=0026251457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026251457&partnerID=8YFLogxK
U2 - 10.1177/030098589102800608
DO - 10.1177/030098589102800608
M3 - Article
C2 - 1771741
AN - SCOPUS:0026251457
SN - 0300-9858
VL - 28
SP - 514
EP - 518
JO - Veterinary pathology
JF - Veterinary pathology
IS - 6
ER -