@inproceedings{87a5065a2c4944e8a8fbf344e3ff33d9,
title = "Entropic trap-based tunable short-pass filter to recover long DNA for genomic applications",
abstract = "We have developed an entropic-based device that filters short DNA to improve sample quality for downstream genetic applications like genome mapping and genome sequencing, providing a marked improvement over conventional methods such as gel electrophoresis. We use microchannel/nanoslit interfaces to sculpt the electric field, thereby trapping long DNA and removing the short DNA. Furthermore, a pressure-driven flow in the microchannel injects and removes DNA from the interface for continuous filtration. Our data demonstrates that this device could both concentrate rare genomic DNA samples and remove impurities in next-generation genomics applications.",
keywords = "Electrophoresis, Entropic trap, Filtration, Lab-on-a-chip, Long DNA, Microchannel, Nanoslits",
author = "Pranav Agrawal and Zs{\'o}fia Bogn{\'a}r and Dorfman, {Kevin D.}",
year = "2020",
month = jan,
day = "1",
language = "English (US)",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1346--1347",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
}