Enzymatic synthesis of oleic acid-based epoxy monomer for the production of value added polymers

Shida Miao, Nicholas Callow, Songping Zhang, Zhiguo Su, Ping Wang, Youyan Liu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


An oleic acid-based epoxy monomer was synthesized by reacting 2-hydroxyethyl acrylate with epoxy stearic acid and an immobilized lipase. NMR, electrospray ionization mass spectrometry and gel permeation chromatography were used to characterize the intermediates and products. 2-(Acryloyloxy) ethyl epoxy stearate was synthesized with a yield of 87 % w/w. After free radical polymerization, epoxy stearic acid-grafted epoxy polymer with molecular weight of 15,150 g/mol was obtained; the final yield was 81 % w/w.

Original languageEnglish (US)
Pages (from-to)887-890
Number of pages4
JournalBiotechnology Letters
Issue number6
StatePublished - Jun 2013

Bibliographical note

Funding Information:
Acknowledgments The authors thank support from the National Natural Science Foundation of China (Grant No. 20728607, 20706054, 20976180), 973 Program (2009CB724705) and 863 Project (2008AA10Z302). Dr. Y. Liu thanks support from Open Funding Project of the National Key Laboratory of Biochemical Engineering (No. 2010KF-15).

Copyright 2014 Elsevier B.V., All rights reserved.


  • Epoxy stearic acid
  • Fatty acid
  • Lipase
  • Monomer
  • Oleic acid
  • Polymer

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