TY - JOUR
T1 - Epigenetics of lung cancer
AU - Langevin, Scott M.
AU - Kratzke, Robert A.
AU - Kelsey, Karl T.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.
AB - Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=84919847817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919847817&partnerID=8YFLogxK
U2 - 10.1016/j.trsl.2014.03.001
DO - 10.1016/j.trsl.2014.03.001
M3 - Review article
C2 - 24686037
AN - SCOPUS:84919847817
SN - 1931-5244
VL - 165
SP - 74
EP - 90
JO - Translational Research
JF - Translational Research
IS - 1
ER -
