Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Lisa S. Chow; Shuzhen Li; Lynn E. Eberly; Elizabeth R. Seaquist; John H. Eckfeldt; Ron C. Hoogeveen; David J. Couper; Lyn M. Steffen; James S. Pankow

doi:10.1016/j.metabol.2012.06.004

Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Lisa S. Chow, Shuzhen Li, Lynn E. Eberly, Elizabeth R. Seaquist, John H. Eckfeldt, Ron C. Hoogeveen, David J. Couper, Lyn M. Steffen, James S. Pankow

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: Evidence from pre-clinical studies suggests inhibition of stearoyl co-A desaturase-1 (SCD-1) activity improves insulin sensitivity. Translation of these findings to humans remains less defined. The purpose of this research was to evaluate the association between different measures of SCD-1 activity and incident diabetes in a large, prospective human study. Methods: In 2738 white participants (aged 45-64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c = 16:1n-7/16:0, SCD18c = 18:1n-9/18:0) and in phospholipids (SCD16p = 16:1n-7/16:0, SCD18p = 18:1n-9/18:0). Incident diabetes was ascertained during 3 follow-up visits. Cox proportional hazards regression was used to determine the association between estimated SCD-1 activity and incident diabetes. Results: During follow-up (mean 8.0 ± SE 2.1 years), 207 (7.6%) participants developed diabetes. After adjusting for age and sex, higher SCD16c, higher SCD16p, and lower SCD18p were significantly associated with incident diabetes. After additional adjustment for education, parental history of diabetes, smoking, dietary intake (carbohydrate, fiber, saturated/monounsaturated/polyunsaturated fat), alcohol use, physical activity, body mass index (BMI), waist-hip ratio, blood pressure, and lipid composition - only SCD16c remained significantly associated with incident diabetes (Hazard Ratio = 1.1 linearly across decreasing quintiles, 95% CI 1.01-1.30; p = 0.03) which remained nominally associated after adjusting for insulin resistance (p = 0.05). Conclusions: In a large community-based prospective cohort study, the estimate of SCD-1 activity by SCD16c had the strongest association with incident diabetes. Refinement of SCD-1 measurement and replication of its association with incident diabetes in an independent cohort is recommended.

Original language	English (US)
Pages (from-to)	100-108
Number of pages	9
Journal	Metabolism: clinical and experimental
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.metabol.2012.06.004
State	Published - Jan 2013

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ).

Keywords

Fatty acid ratio
Prospective study
Type 2 Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Chow, L. S., Li, S., Eberly, L. E., Seaquist, E. R., Eckfeldt, J. H., Hoogeveen, R. C., Couper, D. J., Steffen, L. M., & Pankow, J. S. (2013). Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study. Metabolism: clinical and experimental, 62(1), 100-108. https://doi.org/10.1016/j.metabol.2012.06.004

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title = "Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study",

abstract = "Objective: Evidence from pre-clinical studies suggests inhibition of stearoyl co-A desaturase-1 (SCD-1) activity improves insulin sensitivity. Translation of these findings to humans remains less defined. The purpose of this research was to evaluate the association between different measures of SCD-1 activity and incident diabetes in a large, prospective human study. Methods: In 2738 white participants (aged 45-64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c = 16:1n-7/16:0, SCD18c = 18:1n-9/18:0) and in phospholipids (SCD16p = 16:1n-7/16:0, SCD18p = 18:1n-9/18:0). Incident diabetes was ascertained during 3 follow-up visits. Cox proportional hazards regression was used to determine the association between estimated SCD-1 activity and incident diabetes. Results: During follow-up (mean 8.0 ± SE 2.1 years), 207 (7.6%) participants developed diabetes. After adjusting for age and sex, higher SCD16c, higher SCD16p, and lower SCD18p were significantly associated with incident diabetes. After additional adjustment for education, parental history of diabetes, smoking, dietary intake (carbohydrate, fiber, saturated/monounsaturated/polyunsaturated fat), alcohol use, physical activity, body mass index (BMI), waist-hip ratio, blood pressure, and lipid composition - only SCD16c remained significantly associated with incident diabetes (Hazard Ratio = 1.1 linearly across decreasing quintiles, 95% CI 1.01-1.30; p = 0.03) which remained nominally associated after adjusting for insulin resistance (p = 0.05). Conclusions: In a large community-based prospective cohort study, the estimate of SCD-1 activity by SCD16c had the strongest association with incident diabetes. Refinement of SCD-1 measurement and replication of its association with incident diabetes in an independent cohort is recommended.",

keywords = "Fatty acid ratio, Prospective study, Type 2 Diabetes",

author = "Chow, {Lisa S.} and Shuzhen Li and Eberly, {Lynn E.} and Seaquist, {Elizabeth R.} and Eckfeldt, {John H.} and Hoogeveen, {Ron C.} and Couper, {David J.} and Steffen, {Lyn M.} and Pankow, {James S.}",

note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ). ",

year = "2013",

month = jan,

doi = "10.1016/j.metabol.2012.06.004",

language = "English (US)",

volume = "62",

pages = "100--108",

journal = "Metabolism: clinical and experimental",

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T1 - Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes

T2 - The Atherosclerosis Risk in Communities (ARIC) study

AU - Chow, Lisa S.

AU - Li, Shuzhen

AU - Eberly, Lynn E.

AU - Seaquist, Elizabeth R.

AU - Eckfeldt, John H.

AU - Hoogeveen, Ron C.

AU - Couper, David J.

AU - Steffen, Lyn M.

AU - Pankow, James S.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ).

PY - 2013/1

Y1 - 2013/1

N2 - Objective: Evidence from pre-clinical studies suggests inhibition of stearoyl co-A desaturase-1 (SCD-1) activity improves insulin sensitivity. Translation of these findings to humans remains less defined. The purpose of this research was to evaluate the association between different measures of SCD-1 activity and incident diabetes in a large, prospective human study. Methods: In 2738 white participants (aged 45-64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c = 16:1n-7/16:0, SCD18c = 18:1n-9/18:0) and in phospholipids (SCD16p = 16:1n-7/16:0, SCD18p = 18:1n-9/18:0). Incident diabetes was ascertained during 3 follow-up visits. Cox proportional hazards regression was used to determine the association between estimated SCD-1 activity and incident diabetes. Results: During follow-up (mean 8.0 ± SE 2.1 years), 207 (7.6%) participants developed diabetes. After adjusting for age and sex, higher SCD16c, higher SCD16p, and lower SCD18p were significantly associated with incident diabetes. After additional adjustment for education, parental history of diabetes, smoking, dietary intake (carbohydrate, fiber, saturated/monounsaturated/polyunsaturated fat), alcohol use, physical activity, body mass index (BMI), waist-hip ratio, blood pressure, and lipid composition - only SCD16c remained significantly associated with incident diabetes (Hazard Ratio = 1.1 linearly across decreasing quintiles, 95% CI 1.01-1.30; p = 0.03) which remained nominally associated after adjusting for insulin resistance (p = 0.05). Conclusions: In a large community-based prospective cohort study, the estimate of SCD-1 activity by SCD16c had the strongest association with incident diabetes. Refinement of SCD-1 measurement and replication of its association with incident diabetes in an independent cohort is recommended.

AB - Objective: Evidence from pre-clinical studies suggests inhibition of stearoyl co-A desaturase-1 (SCD-1) activity improves insulin sensitivity. Translation of these findings to humans remains less defined. The purpose of this research was to evaluate the association between different measures of SCD-1 activity and incident diabetes in a large, prospective human study. Methods: In 2738 white participants (aged 45-64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c = 16:1n-7/16:0, SCD18c = 18:1n-9/18:0) and in phospholipids (SCD16p = 16:1n-7/16:0, SCD18p = 18:1n-9/18:0). Incident diabetes was ascertained during 3 follow-up visits. Cox proportional hazards regression was used to determine the association between estimated SCD-1 activity and incident diabetes. Results: During follow-up (mean 8.0 ± SE 2.1 years), 207 (7.6%) participants developed diabetes. After adjusting for age and sex, higher SCD16c, higher SCD16p, and lower SCD18p were significantly associated with incident diabetes. After additional adjustment for education, parental history of diabetes, smoking, dietary intake (carbohydrate, fiber, saturated/monounsaturated/polyunsaturated fat), alcohol use, physical activity, body mass index (BMI), waist-hip ratio, blood pressure, and lipid composition - only SCD16c remained significantly associated with incident diabetes (Hazard Ratio = 1.1 linearly across decreasing quintiles, 95% CI 1.01-1.30; p = 0.03) which remained nominally associated after adjusting for insulin resistance (p = 0.05). Conclusions: In a large community-based prospective cohort study, the estimate of SCD-1 activity by SCD16c had the strongest association with incident diabetes. Refinement of SCD-1 measurement and replication of its association with incident diabetes in an independent cohort is recommended.

KW - Fatty acid ratio

KW - Prospective study

KW - Type 2 Diabetes

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Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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