Estimatien of Infectious Potential of Blood Containing Human Immunodeficiency Virus

John E Connett, F. S. Rhame, J. Thomas, Chap T Le

Research output: Contribution to journalArticlepeer-review

Abstract

A method is described for estimating the probability that transfusion of a given quantity of blood from an AIDS‐infected donor will result in infection in the recipient. The method is based on maximum likelihood, and requires the assumption that individual viruses act independently in causing infection. Results of simulations indicate that the resulting estimates have low bias. The method is applicable to a wide variety of other problems.

Original languageEnglish (US)
Pages (from-to)781-789
Number of pages9
JournalBiometrical Journal
Volume32
Issue number7
DOIs
StatePublished - 1990

Keywords

  • AIDS
  • HIV infection
  • Maximum likelihood

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