TY - GEN
T1 - Estimation of activation sequence from time course of equivalent current density in pathological hearts - A simulation study
AU - Zhou, Zhaoye
AU - Liu, Chenguang
AU - Han, Chengzong
AU - He, Bin
PY - 2011
Y1 - 2011
N2 - The equivalent current density (ECD) model has been previously used in the cardiac electrical imaging technique for non-invasively reconstructing the global activation sequence (AS) in the normal heart. However, its performance in estimating AS in the heart with structural defects remains uncertain. This study aims to evaluate its feasibility in two common cardiac structure diseases-ischemia and infarction, by performing forward simulation using a cellular automaton heart model. The AS was derived from ECD and quantitatively compared to the true AS simulated with the heart model by calculating correlation coefficient (CC) and relative error (RE). In ischemia condition, the ECD model returns a CC (0.97) and RE (0.13), comparable with those of normal heart. In infarction condition, it is also able to identify area of infarction and reconstruct global AS at the excitable myocardium with CC of 0.97 and RE of 0.12. The present pilot simulation results suggest the feasibility of applying ECD model in the pathological heart, which would help the investigation of pathology mechanism and clinical management of cardiac diseases.
AB - The equivalent current density (ECD) model has been previously used in the cardiac electrical imaging technique for non-invasively reconstructing the global activation sequence (AS) in the normal heart. However, its performance in estimating AS in the heart with structural defects remains uncertain. This study aims to evaluate its feasibility in two common cardiac structure diseases-ischemia and infarction, by performing forward simulation using a cellular automaton heart model. The AS was derived from ECD and quantitatively compared to the true AS simulated with the heart model by calculating correlation coefficient (CC) and relative error (RE). In ischemia condition, the ECD model returns a CC (0.97) and RE (0.13), comparable with those of normal heart. In infarction condition, it is also able to identify area of infarction and reconstruct global AS at the excitable myocardium with CC of 0.97 and RE of 0.12. The present pilot simulation results suggest the feasibility of applying ECD model in the pathological heart, which would help the investigation of pathology mechanism and clinical management of cardiac diseases.
KW - Activation Sequence
KW - Cellular Automaton Heart Model
KW - Equivalent Current Density
KW - Infarction
KW - Ischemia
UR - http://www.scopus.com/inward/record.url?scp=79960670954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960670954&partnerID=8YFLogxK
U2 - 10.1109/NFSI.2011.5936837
DO - 10.1109/NFSI.2011.5936837
M3 - Conference contribution
AN - SCOPUS:79960670954
SN - 9781424482818
T3 - 2011 8th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the 2011 8th International Conference on Bioelectromagnetism, NFSI and ICBEM 2011
SP - 139
EP - 141
BT - 2011 8th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the 2011 8th International Conference on Bioelectromagnetism, NFSI and ICBEM 2011
T2 - 2011 8th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the 2011 8th International Conference on Bioelectromagnetism, NFSI and ICBEM 2011
Y2 - 13 May 2011 through 16 May 2011
ER -