Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors

Y. J. Abul-Hajj; R. Iverson; D. T. Kiang

doi:10.1016/0039-128X(79)90020-5

Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors

Y. J. Abul-Hajj, R. Iverson, D. T. Kiang

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Abstract

The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens.

Original language	English (US)
Pages (from-to)	477-484
Number of pages	8
Journal	Steroids
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/0039-128X(79)90020-5
State	Published - Apr 1979
Externally published	Yes

Bibliographical note

Funding Information:
This investigation was supported in part by Public Health Service Grant CA20530 from the National Cancer Institute. The authors wish to thank Dr. Frank Ungar for helpful discussions and critical revision of the manuscript.

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title = "Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors",

abstract = "The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens.",

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AU - Iverson, R.

AU - Kiang, D. T.

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N2 - The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens.

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Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors

Abstract

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