Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: The Multi-Ethnic Study of Atherosclerosis

Teri A. Manolio, Alice M. Arnold, Wendy Post, Alain G. Bertoni, Pamela J. Schreiner, Ralph L. Sacco, Mohammed F. Saad, Robert L. Detrano, Moyses Szklo

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Ethnic differences in non-invasive measures of atherosclerosis are increasingly being reported, but the relationship of these measures to each other has not been widely explored. Carotid ultrasonographic and computed cardiac tomographic findings were compared in 6814 participants of White, Black, Hispanic, and Chinese ethnicities free of overt cardiovascular disease. Coronary calcium and carotid atherosclerosis were strongly related to each other in all ethnic groups. Associations of coronary calcium prevalence and common carotid intimal-medial thickness (IMT) differed by ethnicity in women, being weakest among Black women (0.07 mm IMT difference between those with and without coronary calcium) compared to the other three groups (0.10-0.12 mm difference, p = 0.007). Estimated percent increments in internal carotid IMT per 10% increment in coronary calcium score were highest in Hispanics (18.5%) and lowest in Blacks (6.1%, p < 0.01). Coronary calcium may be less strongly associated with carotid atherosclerosis in Blacks, particularly Black women, than in other ethnic groups. These differences should be pursued for relationships to coronary events to determine whether coronary calcium carries the same risk information in other ethnic groups as it does in Whites.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalAtherosclerosis
Volume197
Issue number1
DOIs
StatePublished - Mar 2008

Bibliographical note

Funding Information:
This research was supported by contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Atherosclerosis
  • Calcium
  • Carotid arteries
  • Epidemiology

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