TY - JOUR
T1 - Ethylene Glycol Poisoning
T2 - Pharmacokinetics during Therapy with Ethanol and Hemodialysis
AU - Peterson, Charles D.
AU - Collins, Allan J.
AU - Himes, Jon Marc
AU - Bullock, Milton L.
AU - Keane, William F.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .
AB - THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .
UR - http://www.scopus.com/inward/record.url?scp=0019364187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019364187&partnerID=8YFLogxK
U2 - 10.1056/NEJM198101013040105
DO - 10.1056/NEJM198101013040105
M3 - Article
C2 - 7432434
AN - SCOPUS:0019364187
SN - 0028-4793
VL - 304
SP - 21
EP - 23
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 1
ER -