Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys

Marilyn E. Carroll, Richard A. Meisch

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalPsychopharmacology
Volume59
Issue number3
DOIs
StatePublished - Jan 1 1978

Keywords

  • Etonitazene HCl
  • Etonitazene concentration
  • Etonitazene drinking
  • Etonitazene reinforcement
  • Fixed-ratio schedules
  • Oral self-administration
  • Rhesus monkeys

Fingerprint Dive into the research topics of 'Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys'. Together they form a unique fingerprint.

Cite this