Abstract
Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.
Original language | English (US) |
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Pages (from-to) | 225-229 |
Number of pages | 5 |
Journal | Psychopharmacology |
Volume | 59 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1978 |
Externally published | Yes |
Keywords
- Etonitazene HCl
- Etonitazene concentration
- Etonitazene drinking
- Etonitazene reinforcement
- Fixed-ratio schedules
- Oral self-administration
- Rhesus monkeys