Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of a double-walled stent-graft (DWSG) design on arterial compliance was evaluated using pulse wave velocity (PWV) measurements in an in vitro mock arterial flow loop. The DWSG prototype was compared to a rigid stent-graft and to an unstented aorta model. The time delay between two pressure sensors a fixed distance apart was used to calculate PWV. Latex tubing simulated the compliant aorta, and a needle valve provided downstream resistance. A series of pulse rates and stroke volumes was applied to enable measurements at different mean pressures for the same system. PWV for the rigid stent-graft was higher than in the other two cases across all mean pressures. The DWSG exhibited behavior similar to the unstented model, demonstrating the capability of the DWSG to maintain aortic compliance in patients requiring an aortic stent-graft.

Original languageEnglish (US)
Title of host publicationFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791883549
DOIs
StatePublished - 2020
Event2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States
Duration: Apr 6 2020Apr 9 2020

Publication series

NameFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020

Conference

Conference2020 Design of Medical Devices Conference, DMD 2020
CountryUnited States
CityMinneapolis
Period4/6/204/9/20

Bibliographical note

Funding Information:
The authors acknowledge the Anatomy Bequest Program at U. Minnesota for providing the pump used in these experiments. This work was supported by NIH NCATS grants TL1R002493 and UL1TR002494, and NIH NHLBI grant U01HL139471.

Publisher Copyright:
Copyright © 2020 ASME

Keywords

  • Arterial compliance
  • Endovascular aortic repair
  • Pulse wave velocity
  • Stent-graft design

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