Evaluation and management of bacterial and fungal infections in patients with a hematological malignancy: A 2018 update

Maria Pia Franco, Jaime S. Green, Jo Anne H. Young

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Bacterial and fungal infections continue to be an unwelcome complication of the treatment of patients with hematological malignancies despite much progress in the oncologic management in recent years. Some new treatment advances and modalities have offered hope to entire new patient populations, but have also opened the door for opportunistic and invasive organisms. Developments in antimicrobial agents, diagnostic methods, and infection control practices have unfortunately not been able to keep up with rapid developments in oncologic therapies nor antimicrobial resistance. Understanding and control of risk factors for antineoplastic therapy-associated immune-suppression, antimicrobial mechanisms and effects, and changing microbial characteristics are key factors to prevention and treatment of bacterial and fungal infection in this complex patient population. This chapter aims to provide a solid understanding of all these principles and factors to enable educated decision-making, considering guidelines and evidence when these exist, and rational recommendations when evidence is lacking for a particular topic.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer International Publishing
Pages1063-1078
Number of pages16
ISBN (Electronic)9783319642635
ISBN (Print)9783319642628
DOIs
StatePublished - Jan 1 2018

Keywords

  • Bacteremia
  • Bacterial infection
  • Febrile neutropenia
  • Fungal infection
  • Fungemia
  • Immune-compromised host
  • Infections in hematological malignancy
  • Neutropenic fever

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