Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of α-MSH-induced melanin production in melanoma B16 cells

P. Thanigaimalai; Ki Cheul Lee; Seong Cheol Bang; Jee Hyun Lee; Cheong Yong Yun; Eunmiri Roh; Bang Yeon Hwang; Youngsoo Kim; Sang Hun Jung

doi:10.1016/j.bmc.2010.01.005

Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of α-MSH-induced melanin production in melanoma B16 cells

P. Thanigaimalai, Ki Cheul Lee, Seong Cheol Bang, Jee Hyun Lee, Cheong Yong Yun, Eunmiri Roh, Bang Yeon Hwang, Youngsoo Kim, Sang Hun Jung

Hormel Institute

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Novel 3,4-dihydroquinazoline-2(1H)-thiones (QNTs) 1 were found to be potent inhibitors of α-MSH-induced melanin production. The effect of QNTs to inhibit melanin formation in B16 melanoma cells was screened in the presence of α-MSH. In defining the mechanism of activity, the effects on tyrosinase activity, on tyrosinase synthesis and on the depigmentation of melanin were evaluated. QNTs did not affect the catalytic activity of tyrosinase, but rather acted as an inhibitor of tyrosinase synthesis.

Original language	English (US)
Pages (from-to)	1555-1562
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.bmc.2010.01.005
State	Published - Feb 15 2010

Bibliographical note

Funding Information:
This research was financially supported by a grant ( R01-2007-000-20099-0 ) from the National Research Foundation of Korea .

Keywords

3,4-Dihydroquinazolines
Depigmentation
Tyrosinase
α-Melanocyte stimulating hormone

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title = "Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of α-MSH-induced melanin production in melanoma B16 cells",

abstract = "Novel 3,4-dihydroquinazoline-2(1H)-thiones (QNTs) 1 were found to be potent inhibitors of α-MSH-induced melanin production. The effect of QNTs to inhibit melanin formation in B16 melanoma cells was screened in the presence of α-MSH. In defining the mechanism of activity, the effects on tyrosinase activity, on tyrosinase synthesis and on the depigmentation of melanin were evaluated. QNTs did not affect the catalytic activity of tyrosinase, but rather acted as an inhibitor of tyrosinase synthesis.",

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AU - Thanigaimalai, P.

AU - Lee, Ki Cheul

AU - Bang, Seong Cheol

AU - Lee, Jee Hyun

AU - Yun, Cheong Yong

AU - Roh, Eunmiri

AU - Hwang, Bang Yeon

AU - Kim, Youngsoo

AU - Jung, Sang Hun

N1 - Funding Information: This research was financially supported by a grant ( R01-2007-000-20099-0 ) from the National Research Foundation of Korea .

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AB - Novel 3,4-dihydroquinazoline-2(1H)-thiones (QNTs) 1 were found to be potent inhibitors of α-MSH-induced melanin production. The effect of QNTs to inhibit melanin formation in B16 melanoma cells was screened in the presence of α-MSH. In defining the mechanism of activity, the effects on tyrosinase activity, on tyrosinase synthesis and on the depigmentation of melanin were evaluated. QNTs did not affect the catalytic activity of tyrosinase, but rather acted as an inhibitor of tyrosinase synthesis.

KW - 3,4-Dihydroquinazolines

KW - Depigmentation

KW - Tyrosinase

KW - α-Melanocyte stimulating hormone

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Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of α-MSH-induced melanin production in melanoma B16 cells

Abstract

Bibliographical note

Keywords

UN SDGs

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