Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases

Smita N. Deshpande; Triptish Bhatia; Joel Wood; Jaspreet S. Brar; B. K. Thelma; Rohan Ganguli; Richard Day; Irving I. Gottesman; Vishwajit L. Nimgaonkar

doi:10.1007/s00127-004-0749-1

Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases

Smita N. Deshpande, Triptish Bhatia, Joel Wood, Jaspreet S. Brar, B. K. Thelma, Rohan Ganguli, Richard Day, Irving I. Gottesman, Vishwajit L. Nimgaonkar

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Abstract

Background. Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia. Aims. The aim of this study was to compare familial influences on the course and severity of schizophrenia in two independent samples. Method. Thirteen selected measures were compared among affected sibling pairs (ASPs) from Pittsburgh, USA and New Delhi, India (48 US pairs, 53 Indian pairs). For each ASP proband, an unrelated patient was selected randomly from a suitable pool of cases ascertained in the same study (Sibpair proband - comparison case or S-C pairs). Correlations between these pairs were compared. Results. The correlations varied by item and by site. Significant correlations for longitudinal course and pattern of severity were noted among the ASPs from USA, but did not remain significant following corrections for multiple comparisons. Comparisons between the correlations for ASPs and the S-C pairs, used to estimate familial effects, yielded trends for the ASP correlations to be numerically larger than the S-C correlations in both samples. Separate cross-site comparisons revealed several significant differences with regard to several demographic and clinical variables. The possible impact of the cross-site variations on the observed ASP correlations is discussed. Conclusions. Though familial factors did not appear to have a significant impact on course/severity using this novel design, the suggestive trends need to be examined in larger samples.

Original language	English (US)
Pages (from-to)	369-374
Number of pages	6
Journal	Social Psychiatry and Psychiatric Epidemiology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1007/s00127-004-0749-1
State	Published - May 2004
Externally published	Yes

Bibliographical note

Funding Information:
■ Acknowledgements We thank two anonymous referees for their helpful comments. This work was supported in part by grants from the NIH (MH01489, MH56242 and MH53459, R03 TW00730 and Indo-US Project Agreement # N-443–645). We thank the following colleagues for help with ascertainment in India. B. R. Angnihotri, K.M.Aggarwal,K.Arora,M.Batra,V.Bhaskar,R.Bhatia,N.Bohra,R.K. Chadha, P. L. Chawla, A. K. Das, S. K. Das, U. Goswami, A. K. Gupta, G. Gupta, R.C. Jiloha, U. Khastgir,A. Kumar, K. Kumar,A. Lal, D.N. Man-dekar, H. Matai, M. N. L. Mathur, S. Mittal, J. Nagpal, R. Nagpal, H. C. Raheja, A. K. Sharma, R. A. Singh, R. K. Singh, S. Nodiyar, P. Dwivedi, Ms. Sushma, Mrs.M. Zutshi, N. Prakash, B. Singh and J.Yadav.

Keywords

Course
Developing country
Familial
India
Schizophrenia
Severity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases",

abstract = "Background. Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia. Aims. The aim of this study was to compare familial influences on the course and severity of schizophrenia in two independent samples. Method. Thirteen selected measures were compared among affected sibling pairs (ASPs) from Pittsburgh, USA and New Delhi, India (48 US pairs, 53 Indian pairs). For each ASP proband, an unrelated patient was selected randomly from a suitable pool of cases ascertained in the same study (Sibpair proband - comparison case or S-C pairs). Correlations between these pairs were compared. Results. The correlations varied by item and by site. Significant correlations for longitudinal course and pattern of severity were noted among the ASPs from USA, but did not remain significant following corrections for multiple comparisons. Comparisons between the correlations for ASPs and the S-C pairs, used to estimate familial effects, yielded trends for the ASP correlations to be numerically larger than the S-C correlations in both samples. Separate cross-site comparisons revealed several significant differences with regard to several demographic and clinical variables. The possible impact of the cross-site variations on the observed ASP correlations is discussed. Conclusions. Though familial factors did not appear to have a significant impact on course/severity using this novel design, the suggestive trends need to be examined in larger samples.",

keywords = "Course, Developing country, Familial, India, Schizophrenia, Severity",

author = "Deshpande, {Smita N.} and Triptish Bhatia and Joel Wood and Brar, {Jaspreet S.} and Thelma, {B. K.} and Rohan Ganguli and Richard Day and Gottesman, {Irving I.} and Nimgaonkar, {Vishwajit L.}",

note = "Funding Information: ■ Acknowledgements We thank two anonymous referees for their helpful comments. This work was supported in part by grants from the NIH (MH01489, MH56242 and MH53459, R03 TW00730 and Indo-US Project Agreement # N-443–645). We thank the following colleagues for help with ascertainment in India. B. R. Angnihotri, K.M.Aggarwal,K.Arora,M.Batra,V.Bhaskar,R.Bhatia,N.Bohra,R.K. Chadha, P. L. Chawla, A. K. Das, S. K. Das, U. Goswami, A. K. Gupta, G. Gupta, R.C. Jiloha, U. Khastgir,A. Kumar, K. Kumar,A. Lal, D.N. Man-dekar, H. Matai, M. N. L. Mathur, S. Mittal, J. Nagpal, R. Nagpal, H. C. Raheja, A. K. Sharma, R. A. Singh, R. K. Singh, S. Nodiyar, P. Dwivedi, Ms. Sushma, Mrs.M. Zutshi, N. Prakash, B. Singh and J.Yadav.",

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T1 - Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases

AU - Deshpande, Smita N.

AU - Bhatia, Triptish

AU - Wood, Joel

AU - Brar, Jaspreet S.

AU - Thelma, B. K.

AU - Ganguli, Rohan

AU - Day, Richard

AU - Gottesman, Irving I.

AU - Nimgaonkar, Vishwajit L.

N1 - Funding Information: ■ Acknowledgements We thank two anonymous referees for their helpful comments. This work was supported in part by grants from the NIH (MH01489, MH56242 and MH53459, R03 TW00730 and Indo-US Project Agreement # N-443–645). We thank the following colleagues for help with ascertainment in India. B. R. Angnihotri, K.M.Aggarwal,K.Arora,M.Batra,V.Bhaskar,R.Bhatia,N.Bohra,R.K. Chadha, P. L. Chawla, A. K. Das, S. K. Das, U. Goswami, A. K. Gupta, G. Gupta, R.C. Jiloha, U. Khastgir,A. Kumar, K. Kumar,A. Lal, D.N. Man-dekar, H. Matai, M. N. L. Mathur, S. Mittal, J. Nagpal, R. Nagpal, H. C. Raheja, A. K. Sharma, R. A. Singh, R. K. Singh, S. Nodiyar, P. Dwivedi, Ms. Sushma, Mrs.M. Zutshi, N. Prakash, B. Singh and J.Yadav.

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N2 - Background. Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia. Aims. The aim of this study was to compare familial influences on the course and severity of schizophrenia in two independent samples. Method. Thirteen selected measures were compared among affected sibling pairs (ASPs) from Pittsburgh, USA and New Delhi, India (48 US pairs, 53 Indian pairs). For each ASP proband, an unrelated patient was selected randomly from a suitable pool of cases ascertained in the same study (Sibpair proband - comparison case or S-C pairs). Correlations between these pairs were compared. Results. The correlations varied by item and by site. Significant correlations for longitudinal course and pattern of severity were noted among the ASPs from USA, but did not remain significant following corrections for multiple comparisons. Comparisons between the correlations for ASPs and the S-C pairs, used to estimate familial effects, yielded trends for the ASP correlations to be numerically larger than the S-C correlations in both samples. Separate cross-site comparisons revealed several significant differences with regard to several demographic and clinical variables. The possible impact of the cross-site variations on the observed ASP correlations is discussed. Conclusions. Though familial factors did not appear to have a significant impact on course/severity using this novel design, the suggestive trends need to be examined in larger samples.

AB - Background. Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia. Aims. The aim of this study was to compare familial influences on the course and severity of schizophrenia in two independent samples. Method. Thirteen selected measures were compared among affected sibling pairs (ASPs) from Pittsburgh, USA and New Delhi, India (48 US pairs, 53 Indian pairs). For each ASP proband, an unrelated patient was selected randomly from a suitable pool of cases ascertained in the same study (Sibpair proband - comparison case or S-C pairs). Correlations between these pairs were compared. Results. The correlations varied by item and by site. Significant correlations for longitudinal course and pattern of severity were noted among the ASPs from USA, but did not remain significant following corrections for multiple comparisons. Comparisons between the correlations for ASPs and the S-C pairs, used to estimate familial effects, yielded trends for the ASP correlations to be numerically larger than the S-C correlations in both samples. Separate cross-site comparisons revealed several significant differences with regard to several demographic and clinical variables. The possible impact of the cross-site variations on the observed ASP correlations is discussed. Conclusions. Though familial factors did not appear to have a significant impact on course/severity using this novel design, the suggestive trends need to be examined in larger samples.

KW - Course

KW - Developing country

KW - Familial

KW - India

KW - Schizophrenia

KW - Severity

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ER -

Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases

Abstract

Bibliographical note

Keywords

UN SDGs

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