Fatigue cracking is one of the dominant distresses in flexible pavements. Therefore, evaluation of fatigue resistance of asphalt mixes is immensely important during the mix design stage. Many researchers have proposed different test methods for characterizing fatigue resistance of asphalt mixes, namely, Four Point Beam Fatigue (BF), Semi-Circular Bend (SCB), Indirect Tensile Test (IDT), Cyclic Direct Tension (CDT), and Overlay Tester (OT). However, in reality, fatigue tests are commonly not practiced in many Departments of Transportation (DOTs) in the U.S.A. Many DOTs avoid fatigue tests probably because of the absence of a consensus for an appropriate fatigue test method, non-uniformity in the test procedures, tediousness in calculations and shortage of trained personnel. Some DOTs may not be in a position to adopt a particular fatigue test method because of lack of significant studies covering fatigue resistance of different types of asphalt mixes and test methods. This paper evaluates fatigue resistance of two different mixes: one prepared with an unmodified (PG 64-22) binder and the other with a polymer-modified (PG 76-28) binder.Two different test methods (BF and SCB) were used. As expected, the results from both these methods indicated that the PG 76-28 mix has better fatigue resistance properties. The repeatability of the test results were studied for both test methods. It was found that a better repeatability in the results can be obtained from the SCB test.