Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

K. M. Meurs, S. G. Friedenberg, B. Williams, B. W. Keene, C. E. Atkins, D. Adin, B. Aona, T. DeFrancesco, S. Tou, T. Mackay

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and Dachshunds. Myxomatous mitral valve disease is a familial disease in human beings as well and genetic mutations have been associated with its development. We hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated with the development of canine MMVD. DNA was isolated from blood samples from 10 CKCS and 10 Dachshunds diagnosed with MMVD, and whole genome sequences from each animal were obtained. Variant calling from whole genome sequencing data was performed using a standardized bioinformatics pipeline for all samples. After filtering, the canine genes orthologous to the human genes known to be associated with MMVD were identified and variants were assessed for likely pathogenic implications. No variant was found in any of the genes evaluated that was present in least eight of 10 affected CKCS or Dachshunds. Although mitral valve disease in the CKCS and Dachshund is a familial disease, we did not identify genetic cause in the genes responsible for the human disease in the dogs studied here.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalVeterinary Journal
Volume232
DOIs
StatePublished - Feb 2018

Bibliographical note

Funding Information:
This study was funded by the Mark L. Morris Jr. Investigator Award, D16CA509, Morris Animal Foundation.

Publisher Copyright:
© 2017 Elsevier Ltd

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Canine
  • Cavalier King Charles spaniel
  • Dachshund
  • Genetic
  • Mitral valve
  • Myxomatous valve

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