Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Medicine & Life Sciences

• nitrosamides 100%
• Nitrosamines 70%
• N'-nitrosonornicotine 61%
• Cytochrome P-450 Enzyme System 50%
• Tobacco 49%
• Butanones 9%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8%
• calf thymus DNA 8%
• DNA Adducts 7%
• Hydroxylation 6%
• Cytochromes 6%
• Catalytic Domain 5%
• In Vitro Techniques 5%
• DNA Damage 5%
• High Pressure Liquid Chromatography 4%
• DNA 3%
• Neoplasms 1%

Chemical Compounds

• Nitrosamine 67%
• Cytochrome 44%
• Pharmacological Metabolism 39%
• Reaction Half Life 24%
• Carcinogenic 13%
• Adduct 9%
• Metabolite 9%
• Oxidation Reaction 5%
• Amount 5%
• pH Value 5%
• Time 4%