TY - JOUR
T1 - Evaluation of periodontal treatments using controlled-release tetracycline fibers
T2 - Clinical response
AU - Drisko, C. L.
AU - Cobb, C. M.
AU - Killoy, W. J.
AU - Michalowicz, B. S.
AU - Pihlstrom, B. L.
AU - Lowenguth, R. A.
AU - Caton, J. G.
AU - Encarnacion, M.
AU - Knowles, M.
AU - Goodson, J. M.
PY - 1995
Y1 - 1995
N2 - The purpose of this investigation was to evaluate the clinical efficacy of controlled release tetracycline fiber therapy in adult periodontitis patients. One hundred-twenty two (122) adult patients from 3 dental centers were enrolled at baseline for this study. Each patient provided at least one site in each of four quadrants that was ≥ 5 mm and bled on probing. One or two such sites were selected as test sites and were randomly assigned to receive one of four treatments: scaling and root planing (S), scaling and root planing plus tetracycline fiber for 10 days (SF), fiber therapy alone for 10 days (F), or two 10-day serial fiber applications (FF). After treatment, no periodontal maintenance or supportive care was provided until the end of this 12 month study, probing depth (PD), clinical attachment level (CAL), plaque, and bleeding on probing (BOP) were measured at baseline and at 1, 3, 6, 9, and 12 months following treatment. Repeated PD and CAL measurements were taken at three locations within each site and averaged for each site. One hundred-sixteen (116) subjects completed the study. All treatments resulted in similar improvements in clinical parameters compared to baseline and were equally effective in the treatment of periodontitis as measured by probing depth reduction, clinical attachment level gain, and reduction of bleeding on probing. The clinical response, established primarily by 3 months following therapy, was generally sustained in all treatment groups for 12 months without the benefit of supportive maintenance therapy.
AB - The purpose of this investigation was to evaluate the clinical efficacy of controlled release tetracycline fiber therapy in adult periodontitis patients. One hundred-twenty two (122) adult patients from 3 dental centers were enrolled at baseline for this study. Each patient provided at least one site in each of four quadrants that was ≥ 5 mm and bled on probing. One or two such sites were selected as test sites and were randomly assigned to receive one of four treatments: scaling and root planing (S), scaling and root planing plus tetracycline fiber for 10 days (SF), fiber therapy alone for 10 days (F), or two 10-day serial fiber applications (FF). After treatment, no periodontal maintenance or supportive care was provided until the end of this 12 month study, probing depth (PD), clinical attachment level (CAL), plaque, and bleeding on probing (BOP) were measured at baseline and at 1, 3, 6, 9, and 12 months following treatment. Repeated PD and CAL measurements were taken at three locations within each site and averaged for each site. One hundred-sixteen (116) subjects completed the study. All treatments resulted in similar improvements in clinical parameters compared to baseline and were equally effective in the treatment of periodontitis as measured by probing depth reduction, clinical attachment level gain, and reduction of bleeding on probing. The clinical response, established primarily by 3 months following therapy, was generally sustained in all treatment groups for 12 months without the benefit of supportive maintenance therapy.
KW - periodontitis/drug therapy clinical trials
KW - tetracycline/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=0029087047&partnerID=8YFLogxK
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U2 - 10.1902/jop.1995.66.8.692
DO - 10.1902/jop.1995.66.8.692
M3 - Article
C2 - 7473012
AN - SCOPUS:0029087047
SN - 0022-3492
VL - 66
SP - 692
EP - 699
JO - Journal of periodontology
JF - Journal of periodontology
IS - 8
ER -