Evaluation of pregnant rabbits as a laboratory model for bovid herpesvirus-4 infection.

K. Naeem, D. D. Caywood, R. E. Werdin, S. M. Goyal

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A field strain (87-8363) of bovid herpesvirus-4 (BHV-4) isolated from an aborted bovine fetus was used to inoculate pregnant rabbits. Eleven rabbits in midgestation were alloted to 4 groups consisting of 3 infected groups and 1 control group. Rabbits were inoculated with BHV-4 or mock-infected cell culture preparations via IV, intravaginal, and intrauterine routes. Mild vulvovaginitis and endometritis were observed after intravaginal and IV inoculation of BHV-4, whereas intrauterine inoculation of BHV-4 resulted in abortion of hemorrhagic fetuses and nonsuppurative endometritis. Virus was successfully isolated from organ explants of fetal tissues. Rabbits seroconverted 1 week after infection as detected by results of an indirect immunofluorescence assay.

Original languageEnglish (US)
Pages (from-to)640-644
Number of pages5
JournalAmerican journal of veterinary research
Volume51
Issue number4
StatePublished - Apr 1 1990

Fingerprint Dive into the research topics of 'Evaluation of pregnant rabbits as a laboratory model for bovid herpesvirus-4 infection.'. Together they form a unique fingerprint.

Cite this